Hardcore DC comics fans know that the great Crisis that destroyed millions of alternate universes began when Krona of the Guardians of Oa broke their most sacred law and used his super science to peer back in time to the very origin of the universe.
Doing so introduced either evil or entropy into the universe depending which version of the story you read and led to the deadly conflict between the Monitor and the Anti-Monitor.
A dozen pan-dimensional Crisis's later the DC universe is only finally returning to much the same shape it was in 1985.
But now disaster stalks the multi-verse again with the same sign:
"I'm not normally a praying man, but if you're up there,
please save me, Superman!” - Homer Simpson